The items we ’re happy to see 99.99 % of the time .
A unsound item in Isaac is n’t even worth picking up since it will either do nothing for you or actively hurt your rill . A proficient item can salvage a run by provide helpful core or by beefing up your stats . The best items can win a run all on their own so long as you roll in the hay what to do with them — RNG unforced , of course .
5. Death Certificate
This point really should n’t be on the inclination , but it is just because it istechnicallythe literal good token in the game . The Death Certificate rent you to a special storey where you could pick an item that you desire . Most of the items are up for grabs save for a peculiar few . By definition , an item that guarantees you the good item in the plot is just as good as the best detail in the plot .
4. Dead Cat
Dead Cat ’s effect is very simple ; it gives you nine lives . Since you normally only have one life history , you’re able to abuse your newfound longevity in Demon Rooms to get top - tier item . It ’s also a godsend on difficult character like the Lost , who normally dies in a New York minute . Just be careful when picking it up ; it position your affectionateness container to one upon pickup .
touch on : How to unlock Downpour in Binding of Isaac Repentance
3. Holy Mantle
One liberal strike in every room may not sound like much , but that chip damage easily builds up over time . It also lets you enter and exit cuss rooms for free , giving you admittance to a new source of item and resources for no cost at all .
2. Godhead
The task of unlocking Godhead is no joke , but once you do , you have one of the single best detail in the Isaac of Isaac . A sizable damage up , a damaging holy halo around your tears , and a homing effect — what more could you expect for from a single detail ?
1. R Key
Want access to a full tally ’s Charles Frederick Worth of workshop , item rooms , gaffer item , Angel and Devil deal chance , and everything else that make out with a footrace ? Want to beat both ? ? ? and the Lamb in the same run ? Well , here you go . All it costs you is your Active item and your time . Good luck .
For aid with an item that certainlyisn’tthe best in the game , go check outAll Pandora ’s Box Effects in The Binding of Isaacon Pro Game Guides !





